Brazil has adopted an adequate strategy for information exchange, enabling patients’ right to access data as well as cross-border data transfers. While Brazil leads the region in research and development (R&D) expenditure and is among the leaders regarding output of academic articles on personalised healthcare, the country can make significant improvements in scale-up funding for small and medium-sized enterprises (SMEs). Brazilian adults tend to rely more on wearables than on the use of connected health devices, even when they are recommended by their physician. Moving forward, Brazil should also prioritise improving availability of neonatal screening for genetic diseases.