The country ranks strongly in cross-border data transfers. In addition, the high output of academic articles and adoption of evidence-based guidelines represents a significant contribution to the advancement of personalised healthcare. Chile has the highest proportion of households with internet access and mobile telephones, making it well-placed to implement personalised healthcare. Universal healthcare coverage (UHC) will continue to help strengthen Chile’s ranking as a top performer in personalised healthcare. Despite the relatively advanced use of personalised technologies and high penetration of telemedicine in hospitals, the country can do more to future proof its healthcare systems and advance personalised healthcare. Stakeholders in Chile should consider increasing accessibility of outcomes data from health institutions.