With a strong background in digital education and the existence of legislation allowing patients to access healthcare data held in EHRs along with a highly capable workforce and a substantial uptake of telemedicine in hospitals, Uruguay is well-placed to implement personalised healthcare. The country could further strengthen its position by developing policies on cross-border data transfers, increasing uptake of electronic health records (EHRs) by healthcare facilities, and improving the quality and accessibility of patient outcome registries. Potential focus areas for Uruguay to improve on include implementation of telemedicine, uptake of wearables, decision support systems and adequacy schemes for cross-border data transfers.