Malaysia is in the process of formulating and implementing plans that aim to enable personalised healthcare and has a digital infrastructure and data collection capabilities that can support limited aspects of personalised care. Increasing investment in research and development, streamlining regulatory processes, opening access to data for research, improving access to digital health services, and building capacity in the healthcare workforce are potential focus areas for Malaysia. In addition, there is a need for a strong emphasis on health equity to address issues of access and quality in Malaysia as it makes its transition to personalised healthcare.