With a robust digital infrastructure, supportive policymaking conditions, and access to advanced technologies, Australia is well poised for the transition to personalised healthcare. Additional strengths include a high level of patient control over their own data and supportive reimbursement structures. However, Australia can do more to futureproof its healthcare system and lead in personalised healthcare. In particular, stakeholders in Australia might consider more comprehensive planning and strategies, implementing strategies for increased interoperability of health data, increased investment in healthcare research and innovation, improving citizen trust in and engagement with the health system. Maintaining a focus on health equity and building additional capacities in the health workforce will also be important to further strengthen Australia’s position.