The greatest strengths in the Asia-Pacific region are in health information, with an overall robust and growing digital infrastructure. On the other hand, there are stark contrasts in policy environments and planning for personalised healthcare, indicating differences in regulatory, innovative, and implementational capacities of jurisdictions in the region. Access to and use of personalised technologies and health services also varies significantly across the Asia-Pacific region. These disparities may be the result of a variety of factors, from differing national priorities, healthcare financing models, and levels of healthcare coverage to myriad social and environmental conditions. To be sure, while some jurisdictions are well-positioned relative to others in the Asia-Pacific region – and may even lead globally – all jurisdictions have ample room to improve their capabilities in personalised healthcare. To lead in personalised healthcare, the Asia-Pacific region could build on its advantages in digital infrastructure and ambition in digital transformation by exploring possibilities for regional data interoperability, develop strategies to combat inequities in access to care and health literacy, and develop stronger policies and regulations for personalised healthcare.