While substantial progress has been made in increasing access to healthcare in India in recent years, large disparities exist between urban and rural areas. Personalised healthcare services have limited availability, often only in more industrialised, urban areas, and cost barriers are significant. To be sure, India has made planning for personalised healthcare a priority. With several policy initiatives and nationwide projects focused on building capabilities in personalised healthcare, India is indeed beginning a transition towards greater personalisation. Moving forward, major challenges for India are likely to be addressing urban-rural disparities, access to care, building digital infrastructure, and securing sufficient levels of health literacy among its population. As a highly federated country, India may also encounter obstacles to achieving data interoperability.